The Board of Trustees of the Leland Stanford Junior University
发明人:
Lynette Cegelski,Ji Youn Lim
申请号：
US13921916
公开号：
US20130338233A1
申请日:
2013.06.19
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Compositions and methods for the dissolution of a microbial biofilm are provided, where the method comprises contacting a microbiofilm with an effective dose of a curcumin derivative as a biofilm inhibitor. In some embodiments the curcumin derivative is dimethoxycurcumin. In some embodiments the biofilm comprises E. coli, e.g. including uropathogenic E. coli. The biofilm can be present in vitro or in vivo. The biofilm inhibitor may be administered alone, or in combination with bacteriocidal agents.
