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T CELL RECEPTORS
专利权人:
发明人:
MOLLOY PETER
申请号:
IN201617000385
公开号:
IN201617000385A
申请日:
2016.01.05
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
The present invention relates to T cell receptors (TCRs) which bind the HLA A2 restricted FMNKFIYEI (158 166) peptide epitope derived from a Fetoprotein (AFP). Certain preferred TCRs of the invention demonstrate excellent binding characteristics and specificity profiles for this AFP epitope. T cell receptors of the invention comprise at least one TCR alpha chain variable domain and/or at least one TCR beta chain variable domain the alpha chain variable domain comprising an amino acid sequence that has at least 90% identity to the sequence of amino acid residues 1 112 of SEQ ID No: 2 and/or the beta chain variable domain comprising an amino acid sequence that has at least 90% identity to the sequence of amino acid residues 1 112 of SEQ ID No: 3.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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