WUNBERG, Tobias,BRUECKNER, Ralph,KESSLER, Dirk,KRAEMER, Oliver,McCONNELL, Darryl,SCHNEIDER, Siegfried,van der VEEN, Lars
申请号：
ES09781207
公开号：
ES2597903T3
申请日:
2009.07.28
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compounds of general formula (1), ** Formula ** in which R 1 represents a group selected from C 3-8 cycloalkyl, 3-8 membered heterocycloalkyl, C 6-10 aryl and 5-12 membered heteroaryl, optionally substituted with one or more identical or different groups selected from Ra, a group independently selected from each other from>； = O, -ORc, haloalkyl C1-3 oxy, -OCF3,>； = S, - SRc,>； = NRc,>； = NORc,>； = NNRcRc,>； = NN (Rg) C (O) NRcRc, -NRcRc -ONRcRc, -N (ORc) Rc, -N (Rg) NRcRc, halogen, -CF3, -CN, -NC, -OCN, -SCN , -NO, -NO2,>； = N2, -N3, -S (O) Rc, -S (O) ORc, -S (O) 2ORc, -S (O) NRcRc, -OS (O) Rc, - OS (O) 2Rc, - OS (O) 2ORc, -OS (O) NRcRc, -OS (O) 2NRcRc, -C (O) N (Rg) NRcRc, -C (O) N (Rg) ORc, - C (NRg) NRcRc, -C (NOH) Rc, - C (NOH) NRcRc, -OC (O) ORc, -OC (O) SRc, -OC (NRg) NRcRc, -SC (O) Rc, -SC (O) ORc, -SC (O) NRcRc, -SC (NRg) NRcRc, - N [C (O) Rc] 2, -N (ORg) C (O) Rc, -N (Rg) C (NRg) Rc, -N (Rg) N (Rg) C (O) Rc, -N [C (O) Rc] NRcRc, -N (Rg) C (S) Rc, -N (Rg) S (O) Rc, - N (Rg) S (O) ORc, -N [S (O) 2Rc] 2, -N (Rg) S (O) 2ORc, -N (Rg) [S (O) 2] 2Rc, -N ( Rg) C (O) SRc, -N (R g) C (O) NRgNRcRc, - N (Rg) N (Rg) C (O) NRcRc, -N (Rg) C (S) NRcRc, - [N (Rg) C (O)] 2Rc, -N ( Rg) [C (O)] 2Rc, -N {[C (O)] 2Rc} 2, -N (Rg) [C (O)] 2ORc, - N (Rg) [C (O)] 2NRcRc, - N {[C (O)] 2ORc} 2, -N {[C (O)] 2NRcRc} 2, - [N (Rg) C (O)] 2ORc, -N (Rg) C (NRg) ORc, - N (Rg) C (NOH) Rc, - N (Rg) C (NRg) SRc, -N (Rg) C (NRg) NRcRc and -N>； = C (Rg) NRcRc and Ra substituted with one or more equal groups or different Rb and / or Rc； and R2 represents a group selected from C3-8 cycloalkyl, 3-8 membered heterocycloalkyl, C6-10 aryl and 5-12 membered heteroaryl, optionally substituted with one or more same or different R5 and R3 represents hydrogen or a group selected from halogen, -ORe, -NReRe, -CF3, -CN, -NC, -NO2 and C1-6 alkyl； and R4 represents a group selected from C1-3 alkyl, C3-8 cycloalkyl, 3-8 membered heterocycloalkyl, -ORe, - NReRe, -CF3, -CN, -NC and -NO2, and each R
