Methods and compositions for enhancing fertility and/or inhibiting pregnancy failure restoring glucose tolerance and/or preventing glucose intolerance and/or maintaining glucose homeostasis and/or inducing or enhancing weight loss treating dyslipidemia treating hypertestosteronism or hyperandrogenism and/or treating type 2 diabetes in an individual in need thereof are provided. These involve compositions that inhibit expression of interferon gamma (IFN ?) or a downstreamIFN ? stimulated gene which is preferably a macrolide immunosuppressant compound.
