The Research Foundation of the State University of New York;Syracuse University Technology Transfer And Industrial Development Office
发明人:
申请号：
EP19189158.9
公开号：
EP3581563A1
申请日:
2011.04.11
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject； (ii) a method of inhibiting a SHIP1 protein in a cell； (iii) a method of selectively inhibiting a SHIP I protein in a cell； (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant； (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2； (vi) a method of ex vivo or in vitro treatment of transplants； (vii) a method of inhibiting tumor growth and metastasis in a subject； (viii) a method of treating a hematologic malignancy in a subject； (ix) a method of inducing apoptosis of multiple myeloma cells； (x) a method of treating multiple myeloma in a subject； (xi) a method of inhibiting the proliferation of a human breast cancer cell； and (xii) a method of treating breast cancer in a subject.
