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INHIBITEURS SHIP ET LEURS UTILISATIONS
专利权人:
The Research Foundation of the State University of New York;Syracuse University Technology Transfer And Industrial Development Office
发明人:
申请号:
EP19189158.9
公开号:
EP3581563A1
申请日:
2011.04.11
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP I protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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