Isaev, Artur Aleksandrovich,Rizvanov, Albert Anatolyevich,Masgutov, Ruslan Faridovich,Bogov, Aleksei Andreevich,Salafutdinov, Ilnur Ildusovich,Deev, Roman Vadimovich,Bozo, Ilya Yadigerovich,Plaksa, Ig
申请号：
AU2015390821
公开号：
AU2015390821A1
申请日:
2015.08.27
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The invention relates to medicine, and more particularly to neurosurgery and trauma surgery, and can be used for stimulating nerve regeneration through the use of a gene therapeutic construct which codes for vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF-2). The gene therapeutic construct that codes for the two factors is based on a codon-optimized recombinant plasmid. The gene therapeutic construct can be introduced either directly into a damaged nerve or into the perineural tissues either during surgery or in the post-operative period. The invention significantly improves the outcomes of the reconstructive treatment of damaged peripheral nerves.
