A pre-filled double chamber syringe (100), comprising: a cylinder (10) that has a cylindrical shape with an axial line (O) as a center and has a branch portion (11) formed due to the bulging of a part of an inner circumferential surface outward； a flared Luer connection (20) provided at the front end of the cylinder； clamping wings (60) provided at the rear end of the cylinder； a front shutter (30) that is fitted on the front end side of the bypass portion in the cylinder； an intermediate plug (40) that is fitted on the rear end side of the bypass portion in the cylinder to seal a preparation (S) together with the front plug； a terminal plug (50) that is fitted on the rear end side of the intermediate plug in the cylinder to seal a solvent together with the intermediate plug； a piston rod (70) that is connected to the terminal plug from the side of the rear end by inserting the clamping wings； a portion of female thread (64) that is formed to curl around the axial line on an inner circumferential surface of the clamping wings； and a male thread portion (73) that is formed so that it can be screwed together with the female thread portion into an outer circumferential surface of the piston rod； characterized by a guide groove (65) that is formed in the female thread portion and extends parallel to the axial line； a guide plate (75) that is formed on the rear end side of the male thread portion on the outer circumferential surface of the piston rod and is guided in accordance with the guide groove； and a first protuberance (66) that is formed at the rear end of the clamping wings and with which the guide plate is arranged to contact, so that it can be overcome, when at least a part of the intermediate shutter, which it can be advanced by rotating the piston rod in accordance with the female thread portion and the male thread portion, moves through the bypass portion.Una jeringuilla precargable de doble cámara (100), que comprende: un cilindro (10) que tiene una forma c
