Larry Brown,Vered Bisker-Leib,Debra LaFreniere,John McGeehan,Julia Rashba-Step,Terrence Scott
申请号：
US11127704
公开号：
US08333995B2
申请日:
2005.05.12
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhancing agent (PSEA) to form a solution in a single liquid phase. The solution is subjected to a liquid-solid phase separation to cause the active agent to form small spherical that are substantially amorphous or non-crystalline and are injectable through fine gauge needles at high concentrations. The invention has special application for higher molecular weight proteins.
