The United States Government as Represented by the Department of Veteran Affairs;Yale University
发明人:
Richard H. Weisbart,Robert N. Nishimura,James E. Hansen,Peter Glazer
申请号：
US16414636
公开号：
US20200129636A1
申请日:
2019.05.16
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention provides methods for selective targeting of live cells, which have undergone or are undergoing radiation or chemotherapy, at a site of interest with a cell-penetrating polypeptide. In one embodiment of the invention, the method comprises contacting the live cells with a cell-penetrating polypeptide comprising cell-penetrating determinants so that the cell-penetrating polypeptide binds extracellular DNA near or around the live cells so as to form a complex or association therewith such that the complex or associated polypeptide-DNA so bound bind the live cells and penetrates the live cells thereby selectively targeting live cells at a site of interest with a cell-penetrating polypeptide.
