The present invention discloses an application of Antrodia camphorata compounds for preparing medicine of kidney disease treatment. The compound is represented by formula I, wherein the kidney disease is glomerulosclerosis or glomerulonephritis. The present invention focuses on six types of compounds extracted from Antrodia camphorata to check if they have the effect for kidney disease treatment and anti-inflammation of kidney.本發明揭露一種牛樟芝化合物在製備治療腎臟疾病之藥物的用途,該化合物係以式I表示:其中該腎臟疾病係為腎絲球硬化症或腎絲球腎炎。