PROBLEM TO BE SOLVED: To provide a composition that, when administered to a patient, leads to the production of endogenous IL-12 in the patient's plasma at a detectable level without causing serious toxicity.SOLUTION: According to the present invention, there is provided a composition capable of causing the appearance of IL-12 in plasma, the composition essentially comprising: a foreign antigen； at least one Th1 cytokine； and a DC maturation molecule.SELECTED DRAWING: None【課題】患者に投与された場合に、重篤な毒性を生じることなく、患者の血漿中の内因性ＩＬ－１２を検出可能なレベルで産生し得るように導く組成物の提供。【解決手段】血漿中にＩＬ－１２の発現を引き起こすことが可能な組成物であって、該組成物は、外来抗原と、少なくとも１つのＴｈ１サイトカインと、ＤＣ成熟分子とを本質的に含む組成物。【選択図】なし
