Crystalline forms of cabozantinib phosphate and cabozantinib hydrochloride

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专利权人:

发明人:

Marijan Stefinovic,Erwin Paul Schreiner

申请号：

US15560527

公开号：

US10053427B2

申请日:

2016.03.22

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention relates to crystalline forms of cabozantinib phosphoric acid salt and cabozantinib hydrochloric acid salt and to a method for their preparation. Furthermore, the invention relates to pharmaceutical compositions comprising said crystalline forms and their use as anti-cancer medicaments. Cabozantinib, i.e. N-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl}-N′-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide is represented by the chemical structure: Formula.

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