Thomas Thisted;Henrik Ravn Aage;Peder Mohr Olsen;Poul Egon Bertelsen
发明人:
Peder Mohr Olsen,Poul Egon Bertelsen,Thomas Thisted,Henrik Ravn Aage
申请号：
US13129664
公开号：
US09101565B2
申请日:
2009.11.17
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a method for the preparation of a tablet comprising at least 50% w/w of calcium carbonate, the method comprisingi) providing a particulate composition comprising a) calcium carbonate, b) a binding sugar alcohol selected from sorbitol or isomalt, or combinations thereof, c) a non-binding sugar alcohol selected from mannitol, maltitol or xylitol, or combinations thereof, andii) compressing said composition using a tabletting machine equipped with at least one pair of punches and dies, wherein the pair of punches and die before filling the die with said particulate composition is sprayed with a composition comprising a lubricant selected from magnesium stearate, calcium stearate or stearic acid or combinations thereof.
