N1 - (4 - (5 - (cyclopropylmethyl) - 1-methyl-1h-pyrazol-4-yl) pyridine-2-yl) cyclohexane-1,4-diamine derivatives and related compounds as CK1 and / or irak1 inhibitors for treating cancer
The present invention relates to a pyrazole derivative of formula (I) as casein kinase 1 (CK1) and / or interleukin 1 receptor related kinase 1 (Iraki) inhibitor, for treatment of cancer, inflammatory disorders, and immune related disorders, especially N1 - (4 - (5) (cyclopropyl methyl) - 1-methyl-l-pira) Cyclohexane-1,4-diamine derivatives and related compounds are provided.1No selection【要約書】本発明は、がん、炎症性障害、及び免疫関連障害を治療するための、カゼインキナーゼ1(CK1)及び/又はインターロイキン1受容体関連キナーゼ1(IRAKI)インヒビターとしての式(I)のピラゾール誘導体、特に、N1-(4-(5-(シクロプロピルメチル)-1-メチル-lH-ピラゾール-4-イル)ピリジン-2-イル)シクロヘキサン-1,4-ジアミン誘導体及び関連化合物を提供する。【化１】【選択図】なし
