The present invention relates to a surface exposed protein (protein E； pE), avirulence factor, which can be detected in Haemophilus influenzae, having anamino acid sequence as described in SEQ ID NO 1, an immunogenic fragment ofsaid surface exposed protein, and a recombinant immunogenic protein (pE (A) )or truncated variants thereof based on said surface exposed protein. Nucleicacid sequences, vaccines, plasmids and phages, non human hosts, recombinantnucleic acid sequences, fusion proteins and fusion products are alsodescribed. A method of producing the said protein or truncated fragmentsthereof recombinantly is also disclosed.
