The invention relates to an ultraviolet toothbrush disinfection device, which comprises a main body, which is a shell, on which there is an opening, inside of which there is a toothbrush placement space; an ultraviolet sterilization device, which is corresponding to the wall surface on one side of the toothbrush placement space, which can emit ultraviolet light to sterilize the toothbrush; and an operation interface, which is corresponding to the main body The operating interface is electrically connected to the UV sterilization device, and the UV sterilization device can be operated through the operating interface.本創作係有關於一種紫外線牙刷消毒裝置,其包含一主體,其係為一殼體,且其上具有一開口,該開口內部具有牙刷置入空間;一紫外光殺菌裝置,其係對應設於該牙刷置入空間之一側壁面上,其可發出紫外光對該牙刷做殺菌;及一操作介面,其係對應設於該主體之表面,且該操作介面係電性連接於該紫外光殺菌裝置,進而可透過操作該操作介面操作該紫外光殺菌裝置。