The present disclosure provides a method for activating adiponectin by administering a composition comprising peptides selected from a casein hydrolysate. Such a composition may reduce risk of heart attack and help in maintaining healthy weight. Preferably, the hydrolysate consists of peptides with a molecular weight of more than 500 Da.本揭露提供一種活化脂聯素之方法,其係藉由施予包含選自酪蛋白水解物之肽類的組成物。該組成物可降低心臟病發作之風險並幫助維持健康體重。較佳地,該水解物係由分子量超過500Da之肽類所構成。