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Pharmaceutical oral dosage form comprising a combination of an opioid agonist and an opioid antagonist
专利权人:
EURO-CELTIQUE S.A.
发明人:
KAIKO, ROBERT, F.,COLUCCI, ROBERT, D.
申请号:
DK10179026
公开号:
DK2266564T3
申请日:
1998.12.22
申请国别(地区):
DK
年份:
2013
代理人:
摘要:
The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative "aversive" experience in physically dependent addicts (e.g., precipitated abstinence syndrome).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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