CHEMICAL AND BIOPHARMACEUTICAL LABORATORIES OF PATRAS S.A.
发明人:
申请号：
IL24598316
公开号：
IL245983D0
申请日:
2016.06.02
申请国别(地区):
IL
年份:
2016
代理人:
摘要：
A first aspect of the invention relates to a single chain insulin analogue comprising: (A) the A-chain of human or animal insulin, or an analogue or derivative thereof (B) the B-chain of human or animal insulin, or an analogue or derivative thereof (C) one or more disulfide bonds between said A-chain and said B-chain and (D) a further covalent link, L, between a functional group of an amino acid in the A-chain and a functional group of an amino acid in the B-chain, at least one of said functional groups being an amino acid side chain functional group. Further aspects of the invention relate to pharmaceutical compositions comprising said single chain insulin derivatives, and therapeutic uses thereof.
