Michael Agadjanyan,Anahit Ghochikyan,Nikolai Petrovsky
申请号：
US15174709
公开号：
US20170239349A1
申请日:
2016.06.06
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present technology relates to compositions comprising inulin particles for use in the enhancement of immune responses to neuronal self-antigens for treating or preventing neurodegenerative diseases, in a subject. Also provided are pharmaceutically acceptable compositions comprising: particles of inulin a substance comprising one or more pathogen-associated molecular patterns (PAMPs) and a neuronal self-antigen fused to carrier, and methods and uses of the composition for inducing or modulating an immune response in a subject, such as modulating an immune response to a neuronal self-antigen as a vaccine. Also provided are vaccine compositions comprising inulin particles, and an antigen-binding carrier material, and methods and uses of the vaccine.
