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Triazole-substituted arylamide derivatives and their use as antagonists of the P2x3 and / or P2x2 / 3 purinergic receptor
- 专利权人:
- F. HOFFMANN-LA ROCHE AG
- 发明人:
- CHEN, LI,DILLON, MICHAEL PATRICK,FENG, LICHUN,HAWLEY, RONALD CHARLES,YANG, MINMIN
- 申请号：
- ES12195604
- 公开号：
- ES2542245T3
- 申请日:
- 2008.12.08
- 申请国别(地区):
- ES
- 年份:
- 2015
- 代理人:
- 摘要：
- A compound selected from the group consisting of: 4'-methyl-5- [1,2,3] triazol-1-yl-biphenyl-3- (2-methoxy-1-methyl-ethyl) -amide 4'-Methyl-5- (5-methyl- [1,2,3] triazol-1-yl) -biphenyl-3-carboxylic acid (2-methoxy-1-methyl-ethyl) -amide, ( 4'-Methyl-5- (5-methyl- [1,2,3] triazol-1-yl) biphenyl-3-carboxylic acid (2) methoxy-1-methyl-ethyl) -amide, ( 5- (5-Isopropyl- [1,2,3] triazol-1-yl) -4'-methyl-biphenyl-3-carboxylic acid (S) -2-hydroxy-1-methyl-ethyl) -amide, 5- (5-Isopropyl- [1,2,3] triazol-1-yl) -4'-methyl-biphenyl-3-carboxylic acid (2-methoxy-1-methyl) -amide, ((R ) 5- (5-Isopropyl- [1,2,3] triazol-1-yl) -4'-methyl-biphenyl-3-carboxylic acid -2-methoxy-1-methyl) -amide, (2 5- (5-Isopropyl- [1,2,3] triazol-1-yl) -4'-methyl-biphenyl-3-carboxylic acid hydroxy-1-methyl-ethyl) -amide, ((S) - 4'-methyl-5- (5-methyl- [1,2,3] triazol-1-yl) -biphenyl-3-carboxylic acid 2-hydroxy-1-methyl) -amide, ((R) 2'-Fluoro-5- (-2-methoxy-1-methylethyl) -amide 2'-Fluoro-5- acid 5-isopropyl- [1,2,3] -triazol-1-yl) -4'-methyl-biphenyl-3-carboxylic acid (2-hydroxy-1-methylethyl) -amide 2-Isopropyl- [1,2,3] -triazol-1-yl) -4'-methyl-biphenyl-3-carboxylic acid, and ((S) -2-hydroxy-1-methyl-ethyl) -amide '-fluoro-5- (5-isopropyl- [1,2,3] -triazol-1-yl) -4'-methyl-biphenyl-3-carboxylic acid.Un compuesto seleccionado de entre el grupo que consiste en: (2-metoxi-1-metil-etil)-amida del ácido 4'-metil-5-[1,2,3] triazol-1-il-bifenil-3-carboxílico, (2-metoxi-1-metil-etil)-amida del ácido 4'-metil-5-(5-metil-[1,2,3]triazol-1-il)-bifenil-3-carboxílico, ((R)-2-metoxi-1-metil-etil)-amida del ácido 4'-metil-5-(5-metil-[1,2,3] triazol-1-il) bifenil-3-carboxílico, ((S)-2-hidroxi-1-metil-etil)-amida del ácido 5-(5-isopropil-[1,2,3] triazol-1-il)-4'-metil-bifenil-3-carboxílico, (2-metoxi-1-metil-etil)-amida del ácido 5-(5-isopropil-[1,2,3] triazol-1-il)-4'-metil-bifenil-3-carboxílico, ((R)-2-metoxi-1-metil-etil)-amida del ácido 5-(5-isopropil-[1,2,3] triazol-1-il)-4'-metil-bifenil-3-carboxílico, (2-hid
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- 中国工程科技知识中心
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- http://www.ckcest.cn/home/
