JEONG EUI JOON,정의준,MOON MI JIN,문미진,KIM JEONG A,김정아,JUNG SUNG YOUB,정성엽
申请号：
KR1020190037321
公开号：
KR1020190114911A
申请日:
2019.03.29
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
The present invention relates to: a conjugate in which an immunoglobulin Fc region is linked to an enzyme and a brain target peptide via a non-peptidyl or peptidic linker； a method for manufacturing the same； and a composition comprising the same. In addition, the conjugate can exhibit improved in vivo persistence, transcytosis, bioavailability, and tissue distribution compared to therapeutic enzymes to which immunoglobulin Fc regions are not bound.COPYRIGHT KIPO 2020본 발명은 면역글로불린 Fc 영역이 비펩타이드성 또는 펩타이드성 링커를 통하여 효소와 뇌 표적 펩타이드에 연결된 결합체, 이의 제조 방법 및 이를 포함하는 조성물에 관한 것이다.
