PROBLEM TO BE SOLVED: To provide pharmaceuticals, foods, cosmetics and the like having Nrf2 expression promoting effect and exerting enhancing the effect of biogenic antioxidant protection and detoxification ability, or to provide materials compounded in these.SOLUTION: An Nrf2 activator containing avocado or an extract thereof as an active ingredient is provided. A preventive, improving, or therapeutic agent of an eye disease selected from retinal degeneration, cataract, as well as corneal and conjunctival disorder, or a renal disease selected from acute renal dysfunction and chronic renal disease, the agent containing avocado or an extract thereof as an active ingredient. An Nrf2 activator containing as an active ingredient one or more selected from persenone A, persenone B, and percine is provided.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】Nrf2発現促進効果を有し、生体の抗酸化防御、解毒能力を高める効果を発揮する医薬品、食品、化粧品等、或いはこれらに配合する素材の提供。【解決手段】アボカド又はその抽出物を有効成分とするNrf2活性化剤。アボカド又はその抽出物を有効成分とする網膜変性、白内障及び角結膜障害から選ばれる眼疾患若しくは急性腎障害及び慢性腎臓病から選ばれる腎臓疾患の予防、改善又は治療剤。ペルセノンA、ペルセノンB及びペルシンから選ばれる1種以上を有効成分とするNrf2活性化剤。【選択図】なし
