GENZYME CORPORATION;EBERHARD KARLS UNIVERSITAT TUBINGEN
发明人:
BLANK, GREGOR,HANDGRETINGER, RUPERT,SCHILBACH, KARIN,LACORCIA, GINA,SNELL, DANIEL,MENRAD, ANDREAS
申请号：
CA2928756
公开号：
CA2928756A1
申请日:
2014.10.30
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present disclosure is related to improved methods for use of a humanized binding polypeptide specific for the alpha beta T cell receptor (aß-TCR). In particular, this disclosure relates to improved methods of use of a humanized anti-aß-TCR antibody, which is derived from the murine monoclonal antibody BMA031, in immunosuppressive therapy. Novel methods using humanized monoclonal antibodies and/or humanized monoclonal antibody fragments (e.g., anti-aßTCR antibodies and/or fragments thereof) are also provided. Novel methods using repetitive administration of humanized monoclonal antibodies and/or humanized monoclonal antibody fragments (e.g., anti-aßTCR antibodies and/or fragments thereof) to reduce aß T cells in the subject relative to ?d T cells in the subject are provided.
