BACHMANN, MARTIN F.,STORNI, TAZIO,MAURER, PATRICK,TISSOT, ALAIN,SCHWARZ, KATRIN,MEIJERINK, EDWIN,LIPOWSKY, GERAD,PUMPENS, PAUL,CIELENS, INDULIS,RENHOFA, REGINA
申请号：
CA2492826
公开号：
CA2492826C
申请日:
2002.09.16
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The invention relates to the finding that virus like particles (VLPs) can beloaded with immunostimulatory substances, in particular with DNAoligonucleotides containing non-methylated C and G (CpGs). Such CpG- VLPs aredramatically more immunogenic than their CpG-free counterparts and induceenhanced B and T cell responses. The immune response against antigensoptionally coupled, fused or attached otherwise to the VLPs is similarlyenhanced as the immune response against the VLP itself. In addition, the Tcell responses against both the VLPs and antigens are especially directed tothe Thl type. Antigens attached to CpG-loaded VLPs may therefore be ....sim.ideal vaccines for prophylactic or therapeutic vaccination against allergies,tumors and other self-molecules and chronic viral diseases.
