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Heat-sensitive composition that prevents tissue adhesion and method of preparation
专利权人:
GENEWEL CO., LTD;HANNAM UNIVERSITY INSTITUTE INDUSTRY-ACADEMIA COOPERATION
发明人:
CHOI, JIN-SUK,LEE, YOUNG-WOO,LEE, YUN-GEE,KIM, JUN-HO,LEE, JIN-HO
申请号:
ES09827667
公开号:
ES2526453T3
申请日:
2009.09.17
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A heat sensitive composition suitable for preventing tissue adhesion, produced by means of a chemical reaction by spraying and stirring c) 0.01 to 2% by weight of a crosslinking agent in an aqueous solution comprising: a. 1 to 50% by weight of a block copolymer having a molecular weight of 1,000 to 500,000 g / mol and comprising a block of poly (ethylene oxide); and b. 0.5 to 1% by weight of a polymer with a molecular weight of 10,000 to 1,000,000 g / mol capable of mixing with the block copolymer a); wherein the crosslinking agent is one or more selected from the group consisting of compounds that include one or more cations selected from the group consisting of Mg2 +, Mn2 +, Ca2 +, Co2 +, Cu2 +, Sr2 +, Ba2 +, Fe2 +; chitosan; glutaradehyde; formalin; poly-L-lysine; polymers of acrylic acid of poly (acrylic acid) and poly (methacrylic acid); a hydroxylamine type dopamine compound; isoleucine, phenylalanine, leucine, threonine, lysine, tryptophan, methionine, valine, histidine, alanine, arginine, asparagine, aspartate, cysteine, glutamine, glutamate, glycine, proline, serine and tyrosine; and in which the difference in viscosity between the upper and lower liquid layers is within 10% when the composition is centrifuged for 3 minutes at 3,000 rpm and 25 ° C.Una composición termosensible adecuada para prevenir la adhesión de los tejidos, producida por medio de una reacción química pulverizando y agitando c) 0,01 a 2% en peso de un agente de reticulación en una disolución acuosa que comprende: a. 1 a 50% en peso de un copolímero de bloques que tiene un peso molecular de 1.000 a 500.000 g/mol y que comprende un bloque de poli(óxido de etileno); y b. 0,5 a 1% en peso de un polímero de un peso molecular de 10.000 a 1.000.000 g/mol capaz de mezclarse con el copolímero de bloques a); donde el agente reticulante es uno o más seleccionado del grupo que consiste en compuestos que incluyen uno o más cationes seleccionados del grupo que consiste en Mg2+, Mn2+, Ca2+, Co2+, Cu2+,
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