Pottayil Govindan N. Sasikumar,Muralidhara Ramachandra,Seetharamaiah Setty S. Naremaddepalli
申请号：
US16343681
公开号：
US20200061030A1
申请日:
2017.10.18
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure relates to 3-substituted 1,2,4-oxadiazole compounds and their derivatives, which are useful as V-domain immunoglobulin suppressor of T-cell activation (VISTA) inhibitors or as dual inhibitors of VISTA and the programmed cell death 1 (PD-1) signaling pathway. The disclosure also relates to treatment of disorders by inhibiting an immunosuppressive signal induced by VISTA and its ligands, PD-1, PD-L1, and/or PD-L2.
