ТАО Чуньлинь (US),ДИСЭЙ Нейл П. (US),СООН-ШИОНГ Патрик (US)
申请号：
RU2012111235/15
公开号：
RU2012111235A
申请日:
2010.08.25
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A method of treating cancer in an individual, comprising administering to the individual: a) an effective amount of a composition containing nanoparticles including taxane and albumin, and b) an effective amount of a hedgehog inhibitor. 2. The method of claim 1, wherein said hedgehog inhibitor inhibits Smoothened activity. The method of claim 1, wherein said hedgehog inhibitor is cyclopamine or a derivative thereof. The method of claim 1, wherein said hedgehog inhibitor is selected from the group consisting of GDC-0449, XL139, IPI926, IPI609 and LDE225.5. The method of claim 1, further comprising administering an effective amount of gemcitabine. The method of claim 3, further comprising administering an effective amount of gemcitabine. The method of claim 1, wherein the cancer is selected from the group consisting of basal cell carcinoma, medulloblastoma, glioblastoma, multiple myeloma, chronic myelogenous leukemia (CML), acute myelogenous leukemia, pancreatic cancer, lung cancer (small cell lung cancer and non-small cell lung cancer), esophageal cancer, stomach cancer, biliary cancer, prostate cancer, liver cancer, liver cell cancer, gastrointestinal cancer, stomach cancer, ovarian and bladder cancer. 8. The method of claim 7, wherein the cancer is pancreatic cancer. The method of claim 7, wherein the cancer is basal cell carcinoma. The method of claim 1, wherein the composition comprising nanoparticles comprising taxane and albumin and a hedgehog inhibitor are administered simultaneously. The method of claim 1, wherein the composition comprising nanoparticles including taxane and albumin and a hedgehog inhibitor are administered sequentially. The method according to any one of claims 1 to 11, wherein the taxon is paclitaxel. The method according to any one of claims 1 to 11, wherein the taxon is docetaxel. The method according to any one of claims 1 to 11, where1. Способ лечения рака у индивидуума, включающий введение индивидууму:a) эффективного количества комп
