Modified endotoxic bacteria lipopolysaccharide (variants) combination of modified lipopolysaccharides (variants) and containing same a vaccine (variants) and a pharmaceutical composition (variants)
APARIN PETR GENNADIEVICH,LVOV VYACHESLAV LEONIDOVICH,ELKINA STANISLAVA IVANOVNA,GOLOVINA MARINA EDUARDOVNA,LEDOV VLADIMIR ALEKSEYEVICH,MARKINA ANNA ALEKSANDROVNA,SHEKHT MARIA EVGEN EVNA
申请号：
IN3691/MUMNP/2015
公开号：
IN2015MN03691A
申请日:
2015.12.26
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
Derived for the first time are individual (without the addition of penta and hexa acyl derivatives) di tri and tetra acyl S LPS of endotoxic bacteria and combinations thereof and the immunobiological physicochemical and chemical pharmaceutical properties thereof have been studied. Shown for the first time is the possibility of the clinical use of same directly in the form of vaccines or pharmaceutical compositions containing modified S LPS individually as a monocomponent active substance or a combination thereof as di and tri component active substances respectively. Modified S LPS and combinations thereof have a high degree of safety and exhibit low pyrogenicity and high immunogenicity. The vaccines and pharmaceutical compositions developed on the basis of the above demonstrate anti shock activity high efficacy and specificity a broad spectrum of activity and good chemical pharmaceutical parameters.
