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Mutant double cyclized receptor peptides inhibiting beta1-adrenoceptor antibodies
专利权人:
Julius-Maximilians-Universitat Wurzburg
发明人:
Lohse, Martin,Jahns, Valerie,Nikolaev, Viacheslav,Jahns, Roland
申请号:
AU2008291296
公开号:
AU2008291296B2
申请日:
2008.08.22
申请国别(地区):
AU
年份:
2014
代理人:
摘要:
The present invention relates to novel β-AR homologous cyclopeptide-mutantscomprising only two cysteine residues able to form an intramolecular linkage,to linear peptides that can form these cyclopeptide-mutants and to nucleic acidmolecules encoding these cyclopeptide-mutants and linear peptides. Moreover,vectors and recombinant host cells comprising said nucleic acid molecule anda method for producing the disclosed cyclopeptide-mutants are provided. Furtherprovided is a composition comprising the peptides, nucleic acid molecules,vectors or host cells of the invention. The present invention also relates totherapeutic and diagnostic means, methods and uses taking advantage of the peptidesof the invention and to means, methods and uses for detecting anti-β-adrenergicreceptor antibodies like anti-βradrenergic receptor antibodies.
来源网站:
中国工程科技知识中心
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