Transgenic non-human mammal that expresses human MMP2

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专利权人:

发明人:

Esteban C. Gabazza,Osamu Taguchi,Tetsu Kobayashi

申请号：

US15103457

公开号：

US09894889B2

申请日:

2014.12.10

申请国别(地区):

US

年份:

2018

代理人:

摘要：

A transgenic non-human mammal has a genome that includes an early-immediate enhancer of human cytomegalovirus (CMV enhancer), a β-actin promoter and the entire gene region of human matrix metalloproteinase 2 (hMMP2) disposed downstream of the promoter. The hMMP2 is systemically expressed in the transgenic non-human mammal, which thus provides a suitable animal model for studying chronic obstructive pulmonary disease and related diseases and conditions.

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