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DOSING REGIMENS FOR THE TREATMENT OF FABRY DISEASE
- 专利权人:
- Inc.;Amicus Therapeutics
- 发明人:
- Greene, Douglas Stuart,Valenzano, Kenneth Joseph
- 申请号：
- AU2016204445
- 公开号：
- AU2016204445B2
- 申请日:
- 2016.06.28
- 申请国别(地区):
- AU
- 年份:
- 2018
- 代理人:
- 摘要：
- #$%^&*AU2016204445B220180322.pdf#####ABSTRACT The presently disclosed subject matter provides a dosing regimen and administration schedule for the use of 1-deoxygalactonojirimycin and enzyme replacement therapy for the treatment of Fabry disease. The presently disclosed 5 subject matter further provides a dosing regimen and administration schedule for the use of migalastat hydrochloride and agalsidase for the treatment of Fabry disease.1/15 Period = ERT Alone -0- 2001-003, 1.0 mg/kg + 2017-001, 0.5 mg/kg +-2018-001, 0.5 mg/kg 3500 -A- 2018-002, 1.0 mg/kg 3000- -- 2018-003, 0.5 mg/kg 2500- + 2018-004, 0.5 mg/kg 200015001000500 0 E 0 2 4 6 8 10 12 14 16 18 20 22 24 Time (hr) Period = Co-Administration -0- 2001-003, 1.0 mg/kg+AT1001 150 mg E + 2017-001, 0.5 mg/kg+AT1001 150 mg +02018-001, 0.5 mg/kg+AT1001 150 mg 3500- -A- 2018-002, 1.0 mg/kg+AT1001 150 mg 3000-2018-003, 0.5 mg/kg+AT1001 150 mg 2500- + 2018-004, 0.5 mg/kg+AT1001 150 mg 2000150010005000 E 0 2 4 6 8 10 12 14 16 18 20 22 24 Time (hr) FIG. 1
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
