Susan Ann Cartlidge;David William Tonge;Xiao-Dong Yang;Gadi Gazit-Bornstein;Olivia Raeber
发明人:
Olivia Raeber,Gadi Gazit-Bornstein,Xiao-Dong Yang,Susan Ann Cartlidge,David William Tonge
申请号：
US13078480
公开号：
US08410058B2
申请日:
2011.04.01
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Binding proteins, such as antibodies directed to IGF-II with cross-reactivity to IGF-I and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the IGF-II with cross-reactivity to IGF-I are disclosed. Also discussed are nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3.
