ORUM THERAPEUTICS INC.;KIM Ji Sun;KIM Yong Sung;PARK Jae Yeong
发明人:
KIM Yong Sung,KIM Ji Sun,PARK Jae Yeong
申请号：
IL26324218
公开号：
IL263242D0
申请日:
2018.11.22
申请国别(地区):
IL
年份:
2018
代理人:
摘要：
The present disclosure relates to a cytosol-penetrating antibody and the use thereof, and more specifically to identification of a structural mechanism that induces escape from endosomes into the cytosol after cellular internalization into living cells through a cell membrane protein, a light-chain variable region and/or heavy-chain variable region, which is based on this identification and has a significantly improved ability to escape from endosomes into the cytosol, a cytosol-penetrating antibody comprising the same, a method for producing the same, and the use thereof.
