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COMPRIMES MONOLITHIQUES A BASE DE COMPLEXES POLYMERES DE CARBOXYLE POUR LA LIBERATION CONTROLEE DE MEDICAMENTS
专利权人:
MATRIPHARM INC.
发明人:
MATEESCU, MIRCEA-ALEXANDRU,LE, TIEN CANH
申请号:
CA2984434
公开号:
CA2984434A1
申请日:
2015.04.28
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
The present document describes a dosage form for delivery of an activeingredient comprising: a first carboxylatedpolymer having carboxyl groups, having a degree of substitution of at least0.2, a molecular weight of at least 200 kDa, and at least30% of said carboxyl groups being complexed with a divalent cation; alone orin a co-complex with at least one of a) a control releasepolymer chosen from an insoluble polymer or a polymer having a reduced watersolubility at 30°C, and a soluble polymer; andb) a second carboxylated polymer having carboxyl groups complexed with adivalent cation. The document also describes processesof making a carboxylated polymer having carboxyl groups, having a degree ofsubstitution of at least 0.2, a molecular weight of atleast 200 kDa, and at least 30% of said carboxyl groups being complexed with adivalent cation, and an inclusion complex, a co-complex,or both comprising the same.
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来源网址:
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