An inhibitor of HCV infection having a high inhibitory effect on HCV infection wherein the effect is unaffected by genotypes or gene mutations of HCV is developed and provided. The present invention provides an anti-occludin antibody binding to a peptide which consists of a portion of an amino acid sequence constituting a second extracellular domain of occludin and contains the amino acid sequence represented by SEQ ID NO: 1 as an epitope.