AIGUADE BOSCH, Jose,GUAL ROIG, Silvia,PRAT QUINONES, Maria,PUIG DURAN, Carlos
申请号：
ES12781362
公开号：
ES2582472T3
申请日:
2012.11.09
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I), or its pharmaceutically acceptable salts or N-oxides or solvates or deuterated derivatives thereof: ** formula ** where * B represents a group of formula (IB): ** Formula ** where - R7 is selected from the group consisting of a hydrogen atom, a linear or branched C1-4 alkyl group and a linear or branched C1-4 alkoxy group, - Ar is selected from the group consisting of a cycloalkyl mono or bicyclic group C3-10 saturated or unsaturated, a C5-C14 aryl mono or bicyclic group, a 3 to 14 membered saturated or unsaturated heterocyclyl or bicyclic group having one or more heteroatoms selected from N, S and O, a mono or bicyclic group 5-14 membered heteroaryl having one or more heteroatoms selected from N, S and O and where the cyclic groups independently are optionally substituted with one or more substituents selected from a halogen atom, a cyano group, a nitro group, a group ox or, a carboxy group, a C1-4 alkyl group, a C1-4 alkoxy group, --CF3, -OCF3, -NReRf, - (CH2) p-OH, -NRe (CO) Rf, -NRe- SO2-R9, -SO2NReRf, -OC (O) Rh and -NRe (CH2) (0-2) -Rj, where p has a value of 0, 1 or 2 and where: - Re and Rf independently represent an atom of hydrogen or a linear or branched C1-4 alkyl group, - Rg is selected from the group consisting of a linear or branched C1-4 alkyl group, a C6-5 aryl group, a saturated or unsaturated C3-8 cycloalkyl, where the Cyclic groups independently are optionally substituted with one or more substituents selected from a halogen atom, a C1-4 alkyl group and a C1-4 alkoxy group, - Rh is selected from a hydrogen atom, -NReRf and a C5 aryl group- 6 which is optionally substituted with one or more substituents selected from a C1-4 alkyl group and a C1-4 alkoxy group, - Ri is selected from the group consisting of a C5-6 aryl group, C3-8 cycloalkyl group and a group 35 het 3 to 8-member saturated or unsaturated erocyclyl, groups that are independently optionally substituted with one or more substituents selected from a halogen ato
