KATOLIK JUNIVERSITI INDASTRI AKADEMIK KOOPEREJSHNFAUNDEJSHN;KHANMI SAJENS KO.; LTD.;KHANMI SAJENS KO., LTD.;KOREJA INSTIT'JUT OF SAJENS EHND TEKNOLODZHI
发明人:
SON Dzung Beom (KR),СОН Дзунг Беом (KR),DZUNG Seung Khiun (KR),ДЗУНГ Сеунг Хиун (KR),ChOJ Va Il (KR),ЧОЙ Ва Ил (KR),DZUNG Joung Khee (KR),ДЗУНГ Йоунг Хее (KR),ChOJ Dzae Jul (KR),ЧОЙ Дзае Юл (KR),SONG,SON DZUNG BEOM,СОН Дзунг Беом,DZUNG SEUNG KHIUN,ДЗУНГ Сеунг Хиун,CHOJ VA IL,ЧОЙ Ва Ил,DZUNG JOUNG KHEE,ДЗУНГ Йоунг Хее,CHOJ DZAE JUL,ЧОЙ Дзае Юл,SONG DZI JEON,СОНГ Дзи Йеон,LI KIU KHANG,ЛИ Киу Ханг,LI
申请号：
RU2012132426/04
公开号：
RU0002524210C2
申请日:
2011.01.31
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
FIELD: chemistry, pharmaceutics.SUBSTANCE: invention relates to thieno[3,2-d]pyrimidine derivative of formula (I) or to its pharmaceutically acceptable salt: (I), where Y stands for -CH=CR1-, -C≡C- or -C(=O)NR1-； L stands for -C(=O)NR2-, -NR2C(=O)- or -NR2C(=O)NR2-； R1 and R2, each independently stands for H； R stands for H, a halogen atom, methyl or methoxy； E stands for phenyl or C3-10heteroaryl, which is non-substituted or substituted with 1-2 substituents, consisting of a group, which includes a halogen atom, -CF3, C1-6alkyl, hydroxy-C1-6alkyl, C3-8cycloalkyl, -(CH2)n-C1-6alkylamino, -(CH2)n-diC1-6alkylamino, -(CH2)nC1-6alkoxy, -(CH2)n-OS(=O)2-C1-6-alkyl, -(CH2)n-phenyl, -(CH2)n-C2-5heteroaryl and -(CH2)n-C4-6heterocycloalkyl, where C3-10heteroaryl represents pyridine, isoquinoline, indole or isoxazole, C2-5heteroaryl of radical -(CH2)n-C2-5heteroaryl represents imidazole or pyrrol, C4-6heterocycloalkyl of radical -(CH2)n-C4-6heterocycloalkyl represents piperazine, morpholine, diazepam, pyrrolidine or piperidine, and phenyl, heteroaryl and heterocycloalkyl each independently, is non-substituted or substituted with substituent selected from a group, which consists of C1-6alkyl, hydroxy-C1-6alkyl, a halogen atom and diC1-6alkylamino, n is equal to 0 or 1； and Z stands for H, -C(=O)R3, C1-6alkyl, hydroxyC1-6alkyl, C3-8cycloalkyl, piperidine, phenyl or pyridine, where piperidine, phenyl and pyridine, each independently, is non-substituted or substituted with C1-6alkyl, C1-6alkoxy or R3-piperazinyl and R3 represents C1-6alkyl or phenyl. The invention also relates to an intermediate compound for obtaining the claimed final compound of formula (I).EFFECT: novel compound, which can be applied in medicine for the prevention or treatment of diseases, characterised by an anomalous growth of cells as a result of an excessive expression of proteinkinase, is obtained.8 cl, 2 tbl, 128 exИзобретение относится к производному тиено[3,2-d]пиримидина формулы (I) или к его фармац
