A drug delivery device for injecting medicament, the device including a main body having a surface for contacting a patient , an actuation button (110 , 420 , 436) movably disposed relative to the main body , and a reservoir disposed within the main body for containing a medicament. The device also includes a needle having a distal end for insertion into a patient, and a lumen extending proximally from the distal end ,wherein said lumen is fluidly connectable with the reservoir. The device further includes a removable needle cover (114 , 400) for selectively covering the distal end of the needle and selectively preventing movement of the actuation button relative to the main body that initiates activation of the device.