The present invention is related to human platelet lysate or a fraction thatis enriched for human platelet lysate derived extracellular vesicles and theirusein medicine, particularly for the prevention and/or treatment of inflammatorydriven diseases, neurodegenerative diseases, immune/autoimmune diseases,cardiovascular diseases, dermatologic diseases, orthopedic diseases, tissueregenerative medicine, oncologic diseases, infectious diseases, transplantrejections, stroke, ischemia or Graft-versus-Host Disease. The presentinventionis further related to a method of manufacture of a pharmaceutical preparationora diagnostic preparation or a cosmetic preparation comprising the step ofaddinghuman platelet lysate or a fraction that is enriched for human platelet lysatederived extracellular vesicles to the pharmaceutical preparation or adiagnosticpreparation or a cosmetic preparation.
