Federalnoe gosudarstvennoe byudzhetnoe obrazovatelnoe uchrezhdenie vysshego obrazovaniya "Rossijskij natsionalnyj issledovatelskij meditsinskij universitet im. N.I. Pirogova" Ministerstva zdravookhraneniya Rossijskoj Federatsii (FGBOU VO RNIMU im. N.I. Pirogova Minzdrava Rossii)
发明人:
Saveleva Galina Mikhajlovna,Kareva Elena Nikolaevna,Shimanovskij Nikolaj Lvovich,Kappusheva Laura Magomedovna,Klimenko Mariya Petrovna,Kuvaeva Viktoriya Dmitrievna,Velichinskij Rodion Albertovich
申请号：
RU20170145663
公开号：
RU2670450(C1)
申请日:
2017.12.25
申请国别(地区):
俄罗斯
年份:
2018
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention relates to a method for predicting the results of in vitro fertilization and embryo transfer in a standard long protocol of stimulation of superovulation. Method consists in selecting peripheral blood in patients on day 21–23 of the menstrual cycle before stimulating superovulation and isolating the mononuclear fraction of blood cells. In cells of the mononuclear blood fraction, the content of the PIBF matrix RNA was determined by real-time PCR and at a level of matrix RNA PIBF more than 0.4 cu predict the success of in vitro fertilization and embryo transfer in the standard long protocol of stimulation of superovulation.EFFECT: use of the invention provides increased availability and increased confidence in determining the probability of success of implantation in patients in a long IVF protocol.1 cl, 1 tbl, 2 ex
