PROBLEM TO BE SOLVED: To obtain Antyusan(a kind of Chinese herbal medicine)-containing tablets excellent in compression moldability and characterized in suppressing delay of the disintegration time.SOLUTION: The Antyusan-containing tablets are obtained by the following procedure: Mixed powder comprising about 3-5 mass% of precipitated silica, a low-substitution-degree hydroxypropyl cellulose, Antyusan powder, an excipient and a lubricant is subjected to dry granulation to prepare Antyusan-containing granules, which are then mixed with a lubricant and such an amount of precipitated silica as to be 6-12 mass%, based on the whole tablets, in the sum with the precipitated silica in the granules followed by making a compression molding.COPYRIGHT: (C)2007,JPO&INPIT【課題】本発明は、圧縮成型性に優れ、しかも崩壊時間の遅延を抑制することを特徴とする安中散含有錠剤を提供することに関する。【解決手段】約3~5質量%の軽質無水ケイ酸、低置換度ヒドロキシプロピルセルロース、安中散末、賦形剤、滑沢剤の混合末を得、該混合末を乾式造粒することにより安中散含有顆粒を製する。ついで顆粒外に該顆粒の軽質無水ケイ酸との和が錠剤全体に対して6~12質量%となる量の軽質無水ケイ酸、及び滑沢剤を混合して、圧縮成型により安中散含有錠剤を得ることができる。【選択図】なし
