2-PHENOXY-AND 2-PHENYLSULFONAMIDE DERIVATIVES WITH CCR3 ANTAGONISTIC ACTIVITY FOR THE TREATMENT OF ASTHMA AND OTHER INFLAMMATORY OR IMMUNOLOGICAL DISORDERS
AXIKIN PHARMACEUTICALS, INC.;ACTIMIS PHARMACEUTICALS, INC.
发明人:
申请号：
IL17106905
公开号：
IL171069A
申请日:
2005.09.22
申请国别(地区):
IL
年份:
2012
代理人:
摘要：
The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of disease associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. wherein X represents O or S； R 4 represents the other substituents are as defined in claim 1.
