Madden, Dean R.,Cushing, Patrick R.,Boisguerin, Prisca,Volkmer, Rudolf,Vouilleme, Lars
申请号：
AU2012336129
公开号：
AU2012336129A1
申请日:
2012.11.05
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.
