Herein are provided a combination of palbociclib and of 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl] -8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing such a combination, and the therapeutic uses thereof, in particular for the treatment of cancer, including breast cancer.本申請提供帕博西尼和6-(2,4-二氯苯基)-5-[4-[(3S)-1-(3-氟丙基)吡咯啶-3-基]氧基苯基]-8,9-二氫-7H-苯并[7]輪烯-2-甲酸或其藥學上可接受的鹽的組合、含有所述組合的醫藥組合物及其治療用途，特別是用於治療癌症包括乳癌的用途。
