Internally controlled cell spray dispenser comprises embodiments that are being used to generate spray by controlling a contact between solutions of different cellular composition and the incoming compressed air produced and triggered by an external source of compressed air. In order to obtain desired quality of spray the present apparatus uses the compressed air regulator, and elastic properties of the air channel valve to control both the circumference of the air channel, and the flow of air in to the frontal cone where the main contact between the two fluids is taking place. Reduced air channel is causing a reduction in flow of air and an increased air pressure in the air channel and in the frontal cone promoting discharge of thicker liquids and larger tissue grafts. Releasing the pressure exerted on the air channel valve is causing the air channel to elastically rebound allowing more air under less pressure to enter the frontal cone promoting a discharge of smaller particles suspended in thinner media.