UNIVERSITE DE BORDEAUX;INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT;CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX;UNIVERSITE LIBRE DE BRUXELLES
发明人:
Philippe Vincendeau,Jean-Loup Lemesre,Etienne Pays
申请号：
US16503687
公开号：
US20190388524A1
申请日:
2019.07.05
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to methods and compositions for preventing, treating and diagnosing infection by trypanosomes. The invention also relates to the use of excreted/secreted antigens (exoantigens, secretome) and specifically to the identification of a protein excreted/secreted by the trypanosomes, the inhibition of which makes it possible to provide effective protection, mainly by vaccination, against infection by trypanosomes or the development or spread thereof. The invention relates to use of the protein, the derivatives thereof, a nucleotide sequence derived from said protein, or an extract enriched with said protein, and to the use of antibodies directed against said trypanosomes for immunotherapy, diagnosis, and monitoring of infections by trypanosomes.
