THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;NOVARTIS AG;UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人:
BROGDON, JENNIFER,JOHNSON, LAURA ALEXANDRA,JUNE, CARL H.,LOEW, ANDREAS,MAUS, MARCELA,SCHOLLER, JOHN,OKADA, HIDEHO
申请号：
CA2901960
公开号：
CA2901960A1
申请日:
2014.02.20
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII, vectors encoding the same, and recombinant T cells comprising the anti- EGFRvIII CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an anti-EGFRvIII binding domain.
