The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ² toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimers disease, Alzheimers disease related disorder, Amyotrophic Lateral Sclerosis, Parkinsons disease, Huntingtons disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on Baclofen and Acamprosate combination.