The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.本發明提供異戊二烯基化類黃酮、芪或此兩者與黃烷或類薑黃素或此兩者之混合物，該等混合物能夠調節關節發炎、關節疼痛、關節僵硬、軟骨降解，或改良移動性、活動範圍、靈活性、關節軀體功能或其任何組合。異戊二烯基化類黃酮、芪或此兩者與黃烷或類薑黃素或此兩者之該混合物可視情況與其他關節管理劑組合使用，該等其他關節管理劑為諸如非類固醇消炎劑/鎮痛劑、COX/LOX抑制劑、葡糖胺化合物、神經痛緩解劑或其類似物。
